A BREAKTHROUGH APPROACH TO JOINT SUPPORT
UC-II® Undenatured Type II Collagen
UC-II® is a patented form of undenatured type II collagen, produced using a proprietary low-temperature process that preserves its natural triple-helix structure. Designed specifically for joint health, UC-II® works differently from conventional collagen supplements.
Rather than acting as a bulk nutritional ingredient, UC-II® supports joints through an immune-mediated mechanism. Clinical studies show that UC-II®, taken in small daily amounts, helps maintain joint comfort, mobility, and cartilage health—making it a trusted choice for long-term joint care.
Why UC-II® Is Different
Most collagen supplements undergo high-temperature processing that alters their natural structure.
These products act primarily as amino acid sources.
UC-II®, however, retains its native three-dimensional structure through a patented low-temperature process. This intact structure allows UC-II® to be recognized by the immune system and to work through oral tolerance, a mechanism that helps maintain a balanced immune response toward joint cartilage.
This innovative approach is what sets UC-II® apart as a next-generation joint support ingredient.
Not All Collagen Is the Same
Collagen comes in many forms, each with distinct sources, structures, and functions in the body.
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Patented UC-II® Undenatured Type II Collagen
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Type II Collagen
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Source
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Chicken sternum cartilage (patented low-temperature extraction)
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Chicken cartilage, fish cartilage, etc.
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Found in
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Joint cartilage
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Joint cartilage, eye vitreous
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Primary role
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Immune modulation + joint cartilage protection
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Maintains cartilage structure & joint function
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Structural State
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Reserves triple-helix native structure
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Mostly hydrolyzed/denatured
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Mechanism of Action
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Modulates immune system via oral tolerance mechanism, specifically targeting joint health
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Provides amino acids as building blocks
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Daily Dosage
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Only 40mg
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1,000-1,500mg
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Target Benefits
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High-efficiency joint health, improved mobility
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Joint health
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Supplementation
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UC-II®'s patented low-temperature process preserves complete triple-helix for unique immune support
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Structure destroyed under high heat (cooking) or acidic conditions
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UC-II® vs Traditional Joint Ingredients
2x More Effective Than Glucosamine + Chondroitin!
In a 90-day clinical study comparing UC-II® with a glucosamine and chondroitin combination:
UC-II® (40 mg/day):
Joint comfort improved by 40%
Joint mobility increased by 20%
Glucosamine (1,500 mg) + Chondroitin (1,200 mg):
Joint comfort improved by 15.4%
Joint mobility increased by 6%
(Crowley et al., 2009, International Journal of Medical Sciences)
The Breakthrough: Immune Modulation vs Nutritional Supplementation
Traditional joint supplements such as glucosamine and chondroitin focus on providing raw materials and are typically taken in high daily doses. UC-II® takes a different approach.
The key difference lies in immune modulation versus nutrient loading. UC-II® delivers meaningful benefits at a fraction of the dosage, supporting joints in a more targeted and efficient way.
UC-II® + Lactoferrin: A Complementary Partnership
UC-II® supports joint cartilage through immune tolerance, while lactoferrin contributes immune-modulating and antioxidant support. Together, they form a complementary system that addresses joint comfort and stability from multiple angles, creating a more complete approach to joint care.
Supports Joint Mobility
Through oral tolerance, UC-II® helps maintain a balanced immune response toward joint cartilage, supporting smoother movement during everyday activities such as climbing stairs or bending.
Less Post-Activity Joint Discomfort
Clinical research shows that UC-II® helps modulate immune responses triggered by physical activity, reducing inflammatory stress on joints and supporting greater comfort and flexibility after movement.
Helps Maintain Cartilage Integrity
Unlike traditional joint ingredients that focus on supplying raw materials, UC-II® works through a unique immune tolerance mechanism, helping reduce immune-driven stress on cartilage and supporting long-term joint stability.
Easier Movement in the Morning
During rest, inflammatory activity can accumulate within joints and contribute to morning stiffness. Through ongoing immune modulation, UC-II® supports a more balanced joint environment overnight, helping joints feel more comfortable upon waking.
SUPPORTED BY MULTIPLE STUDIES
UC-II® Undenatured Type II Collagen
Cartilage Metabolism Support
Increases Knee Cartilage Thickness by Up to 17%
A 24-week study[1] involving individuals with knee joint concerns showed that daily supplementation with 40 mg UC-II® was associated with measurable improvements in cartilage thickness.
UC-II® significantly increased knee cartilage thickness (up to 17.6%) and reduced cartilage fragmentation, demonstrating powerful cartilage protection and metabolic improvement effects.
Enhances Knee Joint Flexibility
Joints Feel 10 Years Younger!?
A study involving 96 healthy adults (ages 20-55[2], with post-activity joint discomfort but no OA history) showed that daily supplementation with 40mg UC-II® for 6 months resulted in significant improvements in knee joint flexion range of motion (ROM), making joints feel "10 years younger."
UC-II® increased knee flexion range 15 times more than placebo, particularly beneficial for healthy individuals aged 35 and above, helping improve daily activity flexibility and exercise performance.
Collapsible content
Reference
[1] Yaremenko et al. (2021). Efficacy, tolerance and influence on cartilage metabolism of undenatured collagen type II (Mercana) in knee OA.
[2] Schon et al. (2022). UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Integrative and Complementary Med 2022;29(6):540-548.
Soucie et al. (2011). Range of motion measurements: reference values and a database for comparison studies. Haemophilia, 17(3):500-507. doi: 10.1111/j.1365-2516.2010.02399.x. Epub 2010 Nov 11.